Cat Number: API184475352

Gefitinib

APIs
CAS Number
184475-35-2
Description
Gefitinib is an EGFR-tyrosine kinase inhibitor.
MolecularWeight
446.9
MolecularFormula
C22H24ClFN4O3
Solubility
Soluble in DMSO (89 mg/ml at 25℃), methanol (20 mg/ml), ethanol (4 mg/ml at 25℃), DMF (20 mg/ml), and water
Storage
Store at -20℃
MeltingPoint
193-194℃
BoilingPoint
~586.8℃ at 760 mmHg
Density
~1.3 g/cm3
RefractiveIndex
1.62
IC50
EGFR: IC50 = 1 nM; HCC827 cell: IC50 = 1.5 nM (human); BA/F3 cells: IC50 = 10.8 nM (mouse); NCI-H292: IC50 = 20 nM; FaDu: IC50 = 50 nM (human)
pKValue
pKb: 7
PreparationUse
Anti-cancer
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