Cat Number: INT95058814

Gecitabine base

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CAS Number

95058-81-4

Synonyms

2'-Deoxy-2',2'-difluorocytidine
2',2'-Difluorodeoxycytidine
Cytidine, 2'-deoxy-2',2'-difluoro-

Description

An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It has a role as a photosensitizing agent, a DNA synthesis inhibitor, a prodrug, an EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor, an environmental contaminant, a xenobiotic, a radiosensitizing agent, an antineoplastic agent, an antimetabolite, an antiviral drug and an immunosuppressive agent.

Molecular Weight

263.2

Molecular Formula

C9H11F2N3O4

SMILES

C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F

EINECS

619-100-6

Appearance

White to Off-white Solid

Boiling Point

482.7±55.0℃ (Predicted)