Cat Number: 92258ES

Galectin-3

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Genus

Human

Source

E.coli

Synonyms

AGE-R3, CBP35, GAL3, L29, LGALS3, Mac-2

Description

Galectin-3, is classified as a chimeric member of the Galectin superfamily. Nuclear Galectin-3 can modulate gene expression, while cytosolic Galectin-3 can inhibit apoptosis. Galectin-3 contributes to the innate immune response against Candida albicans and Streptococcus pneumoniae, and it can facilitate acute inflammatory responses via neutrophil activation and opsonization, macrophage recruitment, and mast cell activation.

Molecular Weight

Approximately 26.0 kDa.

Purity

> 90% by SDS-PAGE.

Biological Activity

Recombinant human Galectin-3 is able to agglutinate red blood cells at a minimum effective concentration of 25µg/ml.

Endotoxin

< 1.0 EU per 1μg of the protein by the LAL method.

Formulation

Lyophilized from a 0.2 µm filtered solution in 1 × PBS, pH 7.4, 1%BSA.

Reconstitution

1.We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile PBS, pH 7.4, with 0.1% BSA to a concentration of 0.1-1.0 mg/mL.
2.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C.
Further dilutions should be made in PBS, which must contain carrier proteins, such as 0.1% BSA, 10% FBS, 5% HSA, 5% trehalose, one of four options.

Note

10, 100, 500μg

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Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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