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Cat Number: API183319699

Erlotinib Hydrochloride

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APIs
CAS Number
183319-69-9
Description
Erlotinib Hydrochloride is a HER-1/EGFR tyrosine kinase inhibitor with anti-neoplastic properties, competitive with ATP.
MolecularWeight
429.9
MolecularFormula
C22H23N3O4•HCl
Appearance
Powder
Solubility
Soluble in DMSO (3 mg/ml), methanol (sparingly), water
Storage
Store at -20℃
MeltingPoint
223-225℃
RefractiveIndex
1.62
IC50
EGFR: IC50 = 2 nM; EGFR activation: IC50 = 20 nM ( Intact cells including HNS human head and neck tumor cells ); Neu: IC50 = 1.52 µM (human); B16-F10: IC50 = 22 mg/ml (mouse); A549: IC50 = 130 mg/ml (human)
pKValue
pKb: 5.32
PreparationUse
Anti-cancer
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