Cat Number: API107724209

Eplerenone

CAS Number

107724-20-9

Description

Eplerenone is an aldosterone antagonist with more specificity for the mineralocorticoid receptor (MCR) than spironolactone, having lower affinity for progesterone, androgen, and glucocorticoid receptors

MolecularWeight

414.491

MolecularFormula

C24H30O6

SMILEs

CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC

Solubility

Soluble in DMSO (10 mM), water (very slightly), ethanol (slightly), methanol (sparingly), and chloroform.

Storage

Store at room temperature

MeltingPoint

241-243ºC

BoilingPoint

597.9±50.0 ℃ at 760 mmHg

Density

1.3±0.1 g/cm³

RefractiveIndex

1.587

OpticalActivity

α20D +2.7, c = 0.44 in chloroform

IC50

MCR: IC50 = 81 nM; MCR: IC50 = 122 nM (human); MCR: IC50 = 0.36 µM; GR: IC50 >8.94 µM (human); PR: IC50 >10 µM (human)

FlashPoint

259.5±30.2 ℃

VapourPressure

0.0±1.7 mmHg at 25℃

PreparationUse

an aldosterone antagonist, as an adjunct in the management of chronic heart failure.

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Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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