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Cat Number: API209216239

Entecavir Monohydrate

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CAS Number

209216-23-9

Synonyms

Entecavir hydrate
entecavir monohydrate
Entecavir (monohydrate)
Entecavir hydrate (JAN)

Description

A synthetic analogue of 2'-deoxyguanosine, entecavir is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. It is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. Enteclavir is used for the treatment of chronic hepatitis B. It has a role as an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor and an antiviral drug.

Molecular Weight

295.29

Molecular Formula

C12H17N5O4

SMILES

C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N.O

EINECS

606-668-5

Appearance

White Powder

Boiling Point

661.4℃ at 760 mmHg