Cat Number: API142217694

Entecavir

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CAS Number

142217-69-4

Description

Entecavir is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.

MolecularWeight

277.28

MolecularFormula

C12H15N5O3

SMILEs

C=C1[C@H](C[C@@H]([C@H]1CO)O)N2C=NC3=C2NC(=NC3=O)N

Solubility

Soluble in water (2.2-3 mg/ml), DMSO, and methanol.

Storage

Store at room temperature

MeltingPoint

238-244℃

BoilingPoint

661.40℃ at 760 mmHg

Density

1.81 g/cm³

RefractiveIndex

1.84

OpticalActivity

α20D +36.8, c = 0.1 in methanol

IC50

Human immunodeficiency virus: EC5050 = 0.1 nM; Hepatitis B virus: EC5050 = 2.4 nM; HepG2: EC5050 = 3 nM (human); HIV-1: EC5050 = 9 µM (MT-2); HIV-PSEUDOTYPED NL4-3: EC5050 = 12.6 µM (HEK-293)

pKValue

pKa: 9.64, pKb: 2.64

FlashPoint

397.9ºC

PreparationUse

a new generation of guanine nucleoside analogues oral medicine for treatment of hepatitis B virus infection

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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