Are you looking for a reliable partner to develop effervescent tablets that provide a convenient and enjoyable way to take medications or nutritional supplements? Look no further! Protheragen-ING offers comprehensive effervescent tablet development services, including formulation, manufacturing, and customization.

Our experienced formulation scientists work closely with you to develop effervescent tablet formulations that meet your specific requirements. We carefully select ingredients and optimize formulations to ensure stability, efficacy, and a pleasant effervescent response. Whether you require a specific active ingredient or a combination of ingredients, we can create customized formulations that precisely meet your specifications.

What are effervescent tablets?

Effervescent tablets are a popular dosage form that combines the benefits of tablets with the effervescent properties of carbonated beverages. It is designed to release carbon dioxide (CO₂) in contact with water, which promotes its disintegration.

Within minutes, the effervescent tablet dissolves completely and the drug becomes a solution. The production of CO₂ is the result of a chemical reaction between a carbonate or bicarbonate (e.g., sodium bicarbonate) and a weak organic acid (e.g., citric acid or tartaric acid) in the presence of water.

Here are some of the main advantages of effervescent tablets:

• Easy to take - Have a small size and evenly dispersed active ingredients, making them easy to chew and swallow.
• Dissolves quickly in water - Provides faster absorption and action of the active ingredient of the drug.
• Easy to carry.
• Good taste - Flavor and mouthfeel improvers can be added.
• Versatile applications.

Multiple Types of Effervescent Tablets

Protheragen-ING specializes in the development of effervescent tablets for a variety of applications, including:

• Pharmaceuticals - We can formulate effervescent tablets for a wide range of active pharmaceutical ingredients, providing an alternative dosage form that is easy to administer and quickly dissolves and absorbs.
• Dietary Supplements - Whether you need effervescent tablets for vitamins, minerals, or other nutritional supplements, we can create formulations that provide optimal bioavailability and a refreshing effervescent experience.
• Sports Nutrition - We understand the unique needs of athletes and fitness enthusiasts. Our experts can develop effervescent tablets that support hydration, electrolyte replenishment, and performance enhancement.

General Manufacturing Process of Effervescent Tablets

Our state-of-the-art manufacturing facilities are equipped with the latest technology to ensure efficient production of effervescent tablets. We follow stringent quality control measures throughout the manufacturing process to ensure consistent and reliable results.

1. Preparation of raw materials

Prepare raw materials required for effervescent tablets, including active pharmaceutical ingredients, excipients, and effervescent agents. We ensure that the quality of the raw materials meets the requirements and carry out the necessary inspections and tests.

2. Powder mixing

The active ingredients and excipients are powder-mixed by using a stirrer or mixer to ensure that they are evenly dispersed.

3. Wet granulation

The blended powder is wet granulated with an appropriate amount of wetting agent to form a granular mixture for the subsequent formulation process. The wetting agent can be water or other solvents.

4. Granulation drying

The pellets after wet granulation are dried to remove moisture and enhance the stability of the pellets.

5. Mixing and tableting

The dried granules are mixed with other excipients such as dispersants, sweeteners, acidulants, etc. to further improve taste and drug stability. The mixture is then pressed into tablets, which is usually accomplished using a rotary tablet press or a tablet press.

6. Coating and packaging

If desired, the effervescent tablets can be coated to enhance their stability and appearance. Finally, the effervescent tablets are packaged, and common forms of packaging include effervescent bottles and aluminum foil packaging.

Fig. 1 Flow diagram showing the sequence of tablet processing to make effervescence tablet. (Iqbal N, et al. 2021)

Contact us today to discuss your effervescent tablet development project and discover how we can help you bring your innovative products to market successfully.