Cat Number: API154598524

Efavirenz

CAS Number

154598-52-4

Description

Efavirenz is a nonnucleoside HIV-1 RT (HIV-1 reverse transcriptase) inhibitor which selectively inhibits the glucuronidation of 3′-Azido-3′-deoxythymidine β-D-glucuronide, Sodium Salt.

MolecularWeight

315.675

MolecularFormula

C14H9ClF3NO2

SMILEs

C1CC1C#C[C@]2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F

Solubility

Soluble in methanol.

Storage

Store at -20℃

MeltingPoint

139-141ºC

BoilingPoint

422.7±55.0 ℃ at 760 mmHg

RefractiveIndex

1.582

OpticalActivity

α20D -84.7, c = 0.5 in chloroform

IC50

HIV-1: IC50 = 0.9 nM (E138K strain); HIV-1: IC50 = 1.7 nM (P225H strain); V108I mutant virus: IC50 = 1.4 nM

pKValue

pKa: 10.24

FlashPoint

209.4±31.5 ℃

VapourPressure

0.0±1.1 mmHg at 25℃

PreparationUse

used in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1(HIV-1) infection

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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