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Cat Number: API120014064

Donepezil

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CAS Number

120014-06-4

Synonyms

2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
Aricept
Donaz

Description

Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nootropic agent and an EC 3.1.1.8 (cholinesterase) inhibitor.

Molecular Weight

379.49

Molecular Formula

C24H29NO3

SMILES

COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC

Appearance

White to Off-white Solid

Boiling Point

527.9

Density, g/cm3

1.141±0.06 (Predicted)