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Cat Number: API1051375166

Dolutegravir

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CAS Number

1051375-16-6

Synonyms

GSK1349572
S/GSK1349572
Tivicay

Description

Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity.

Molecular Weight

419.4

Molecular Formula

C20H19F2N3O5

SMILES

CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O

EINECS

809-888-1

Appearance

White to off-white (Solid)

pKa

8.2