Cat Number: PIPB-0240

DMT-2'-Fluoro-dG(Ib) Phosphoramidite

CAS Number

144089-97-4

Synonyms

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];DMT-2FLUORO-DG(IB) AMIDITE;DMT-2'-F-dG(iBu)-CE Phosphoramidite;2'-F-dG(iBu)-CE Phosphoramidite;5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-Deoxy-guanosine 3'-CE phosphoramidite;N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide;ibu-2'-F-dG Phosphoramidite;2'-fluoro-N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-deoxyguanosine-3'-CE-Phosphoramidite

Description

DMT-2''Fluoro-DG(IB) amidite (CAS# 144089-97-4) is a nucleoside used in the preparation of cyclic dinucleotide compounds, and in the preparation of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides, which improve metabolic stability and elicit efficient RNAi-mediated gene silencing.

Molecular Weight

857.91

Molecular Formula

C44H53FN7O8P

InChI

CFFUQMXILRDKMM-QPYLYBSMNA-N

InChIKey

CFFUQMXILRDKMM-QPYLYBSMNA-N

SMILES

C(NC1=NC(=O)C2=C(N1)N([C@H]1[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C(C)C |&1:10,11,13,28,r|

Appearance

powder

Color

white to off-white

Storage

-20℃

Purity

≥98%

pKa

9.16±0.20(Predicted)

Specification

100 g;kg