Cat Number: API13739021

Diacerein

CAS Number

13739-02-1

Description

Diacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.

MolecularWeight

368.294

MolecularFormula

C19H12O8

SMILEs

CC(=O)OC1=CC=CC2=C1C(=O)C3=C(C=C(C=C3C2=O)C(=O)O)OC(=O)C

Appearance

Crystalline powder

Solubility

Soluble in water (partly), DMSO, and methanol.

Storage

Store at room temperature.

MeltingPoint

217-218ºC

BoilingPoint

631.5±55.0 ℃ at 760 mmHg

Density

1.5±0.1 g/cm³

RefractiveIndex

1.634

IC50

Female germline-specific tumor suppressor gld-1: IC50 = 7.31 µM (caenorhabditis elegans); Caspase-3: EC5050 = 7.89 µM (human); Heat shock protein HSP90: IC50 = 9.23 µM (human); Caspase-7: EC5050 = 14.80 µM (human); Protein Rev: IC50 >75.41 µM (Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1))

pKValue

pKa: 3.01

FlashPoint

231.8±25.0 ℃

VapourPressure

0.0±1.9 mmHg at 25℃

PreparationUse

a novel interleukin (IL)-1 inhibitor, an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis.

QualitySpecification

Standard

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed