Cat Number: API24584096

Dexrazoxane

CAS Number

24584-09-6

Description

Dexrazoxane, also referred to as ADR-529, is an organo-metallic compound widely employed in scientific research. It inhibits Topo II (DNA topoisomerase II) without inducing DNA strand breaks. Dexrazoxane is a (+)enantiomer of razoxane (sc-253425). Dexrazoxane also decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway. Furthermore, dexrazoxane is thought to inhibit the activity of topoisomerase II.

MolecularWeight

268.269

MolecularFormula

C11H16N4O4

SMILEs

C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

Appearance

Powder

Solubility

Solubility: Soluble in DMSO

Storage

Store at room temperature

MeltingPoint

194-196ºC

BoilingPoint

531.5±50.0 ℃ at 760 mmHg

RefractiveIndex

1.54

FlashPoint

275.3±30.1 ℃

VapourPressure

0.0±1.4 mmHg at 25℃

PreparationUse

a cardioprotective compound against anthracyclines, as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients.

QualitySpecification

in-house

Standard

in-house

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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