Description
Cytosine β-D-arabinofuranoside hydrochloride is a DNA synthesis inhibitor and anti-leukemic agent.
MolecularFormula
C9H13N3O5•HCl
Appearance
Crystalline powder
Solubility
Soluble in water (50 mg/ml).
MeltingPoint
197-198℃ (lit.)
OpticalActivity
α20D +160.5±5.5, c = 1 in water
IC50
P12-Ichikawa: IC50 = 5.54 nM (human); CCRF-CEM: IC50 = 6 nM (human); SF268: IC50 = 7.68 nM (human); L1210: IC50 = 10 nM (human); MOLT-4: IC50 = 10 nM (human)
Specification
Antitumor drugs
PreparationUse
Cytarabine hydrochloride for injection (50/100 mg)
Standard
Chinese Pharmacopoeia 2015 Edition Part 2