Cat Number: PIPE-0561

Cyclopamine

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CAS Number

4449-51-8

Synonyms

11-Deoxojervine
11-Deoxyjervine
Jervine, 11-deoxo-

Description

Cyclopamine is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

Molecular Weight

411.6

Molecular Formula

C27H41NO2

EINECS

628-058-8

SMILES

CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1

Appearance

White Crystal Powder

Storage

Room temperature