Coupled Targeted Delivery Services

The concept of coupled targeted drug delivery involves the use of multiple components that act synergistically to achieve enhanced and targeted delivery of drugs to specific sites in the body. These components can include various types of drugs, carriers, targeting ligands, and stimulus-response systems. By coupling different components, a more precise and controlled drug release at the target site can be achieved.

Protheragen-ING is committed to revolutionizing the field of drug delivery by providing advanced solutions that precisely target specific tissues or cells in the body. With our expertise in developing target-specific binding modules, we offer a range of options to enhance the efficacy and safety of drug therapy. Our innovative approach holds great promise for personalized medicine and improved treatment outcomes.

Our Target-Specific Binding Modules

In our services, we offer a variety of target-specific binding modules for coupled targeted drug delivery. These modules include but are not limited to:

• GalNAc (N-acetylgalactosamine) coupling modifications

GalNAc coupled modification is a biologically important form of glycosyl modification that plays an important role in cell signaling, cell adhesion, immune response, and disease development. Specific targeted delivery is achieved by binding drugs to GalNAc-modified carriers.

• Antibody-based coupled targeting

Our antibody-based modules utilize monoclonal antibodies that can recognize and bind to unique antigens expressed on the surface of specific cells or tissues. This approach enables highly specific drug delivery and minimizes off-target effects.

• Ligand-receptor coupled targeting

By utilizing ligands that specifically bind to cell surface receptors, we can facilitate targeted drug delivery to cells that express these receptors. This approach utilizes the natural binding mechanisms present in the body to promote efficient drug absorption.

• Nucleic acid-drug coupling systems

Utilizes the specific recognition ability of nucleic acid molecules to efficiently deliver drugs to specific cells or tissues. Our nucleic acid coupling systems provide efficient drug release and targeting precision for the treatment of genetically related diseases.

• Peptide-drug based coupled targeting

Peptides provide a versatile platform for coupled-targeted drug delivery. We design and develop peptides that selectively bind to specific receptors or cell surface markers, enabling precise drug delivery to the desired location.

• Non-coding RNA-coupled systems

By combining non-coding RNAs and drugs, we have developed an innovative coupled targeting system that enables targeted delivery and specific action of drugs by exploiting the regulatory functions of non-coding RNA molecules.

Fig. 1 a. Ligand-directed liposomal oligonucleotides (ONs) nanoparticles; b. Ligand-directed polymer-ON nanoparticles. (Yu B, et al. 2009)

Features of our modules

• Highly customizable.
• Excellent specificity.
• Achieve higher drug accumulation at desired sites.
• Provides controlled release of drug payload.
• Biocompatibility and safety.

We are committed to providing you with customized coupled targeted drug delivery solutions to open up new possibilities for disease treatment. If you are interested in our services or have any questions, please feel free to contact us.