Introduction:

Taste and odor correction has a positive mental and psychological effect in the treatment of diseases and is an important tool to improve patient compliance. Corrective excipients are a class of substances that can mask or correct the undesirable odor or tastes of drugs, making the finished drug more palatable and easier for patients to take. Corrective excipients are widely used in oral formulations.

Methods of correcting

1. Mechanical methods: masking the bad odor of the drug, such as capsule, or tablets which are wrapped by sugar coating to achieve the purpose of correcting the odor and tastes.
2. Chemical methods: modifying the structure of some active pharmaceutical ingredients with unpleasant odor into a new compound with the same pharmacological effect, can also achieve the purpose of correcting taste and odor.
3. Pharmacological methods: referring to the technique of incorporating flavoring compounds into the formulation, which is most frequently employed in pediatric medicine to increase patient compliance by disguising the unpleasant smell of the treatment or enhancing its taste.

Subtypes of Corrective Excipients:

1. Sweetening agents: Sweeteners are substances with a sweet taste, including natural and synthetic sweeteners.
   Natural sweeteners: a class of high-calorie sweeteners, mainly including sugar, sugar alcohols, glycosides, including sugar in the sucrose and simple syrup is most widely used. Glycerol, sorbitol, and other polyols are frequently mixed in formulations to prevent the precipitation of sucrose crystals. Syrups made from fruit juices like orange, cherry, and others are also frequently used as sweeteners.
   Synthetic sweeteners: No- or low-calorie sweeteners, tens to hundreds of times sweeter than sucrose, are becoming more popular. Mainly includes saccharin sodium, aspartame, etc.
2. Aromatics: are compounds used to enhance the odor of medications in the creation of pharmaceuticals, including natural aromatics and synthetic aromatics.
   Natural aromatics: include natural aromatic oils and their preparations, often containing complex ingredients like orange peel tincture, cinnamon oil, and peppermint water, typically need to be extracted, concentrated, purified, and identified before use.
   Synthetic aromatics: alcohols, aldehydes, ketones, esters, terpenes, and other tastes are used to create, with ester scents being the most popular.
3. Mucilagines: an excipient has a viscous and soothing property, which can prevent the drug from spreading to the taste buds, interfere with the taste of the taste buds, and reduce the irritation of the drug, so it can taste. Adding sweeteners to mucilagines can increase the flavor of the gelatin. flavoring effect. Commonly used colloids are starch, gum arabic, sodium carboxymethyl cellulose, gelatin, agar, etc.
4. Effervescent: made by mixing bicarbonate with organic acid such as citric acid or tartaric acid, and suitable auxiliary materials. The effervescent agent can produce a large amount of carbon dioxide when it meets water, and it becomes acidic after being dissolved in water, which can paralyze the taste buds and achieve the purpose of flavoring.

Conclusion:

Corrective excipients are essential components in the development of solid dosage forms. By carefully selecting and incorporating these excipients, pharmaceutical companies can enhance the therapeutic impact of their products, improving patient outcomes and experiences. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.