Colloidosomes represent a versatile platform for the design of advanced materials and are of great interest due to their potential applications in various fields such as drug delivery, controlled release systems, encapsulation of active compounds, and templates for nanomaterial synthesis.

Protheragen-ING specializes in the design and fabrication of advanced colloidosomes systems. We are committed to pushing the boundaries of colloidosomes research and development to provide cutting-edge solutions to meet our customers' specific requirements. With our expertise and state-of-the-art facilities, we are committed to delivering superior results and unlocking the full potential of colloidosomes systems.

Colloidosomes: An Overview

Colloidosomes are fascinating structures formed by colloidal particles that self-assemble at the interface between two immiscible fluids, usually oil and water. These structures resemble hollow capsules or shells, with the colloidal particles tightly packed at the interface.

Fig. 1 Colloidosomes. (Thompson KL, et al. 2015)

The original self-assembled structures are known as Pickering emulsions. The preparation of colloidosomes requires a mechanism of shell reinforcement at the interface to convert the Pickering emulsion precursor into a robust microcapsule that can survive the removal of the oil/water template.

Unique properties of colloidosomes:

• High Surface Area - Ideal for adsorption, encapsulation and catalytic applications.
• Adjustable Properties - Customize the size, shape and composition of the colloidosomes.
• Encapsulation and Controlled Release - Controlled by changing shell properties or by external stimuli such as pH, temperature, or light.
• Biocompatible.

What Can We Do for You?

Protheragen-ING offers a comprehensive range of colloid development services designed to meet the diverse needs of our clients. Services include:

• Colloidosome Design and Synthesis.
• Encapsulation and Controlled Release.
• Functionalization and Surface Modification.
• Characterization and Analysis.

Advantages of Our Colloidal Systems

Choosing our colloidal systems development service offers numerous advantages for your research or industrial applications. Some of the key benefits include:

• Tailored Design.
• Versatility and Customizability.
• Enhanced Stability.
• Controlled Release.
• Advanced Functionality.

Process of Colloidosomes Preparation

In general, the preparation of colloidosomes via Pickering emulsions involves three major steps.

1) The to-be-adsorbed nanoparticles are dispersed in the oil/water mixture to generate emulsification of two immiscible phases: oil-in-water (o/w) and water-in-oil (o/w) emulsions.

2) Subsequent interfacial reinforcement is required to crosslink the colloidal particles into robust microcapsules. In-situ covalent cross-linking with compatible cross-linkers at ambient temperatures allows for permanent stabilization of colloidosomes capable of surviving in different solvents without morphological distortion or fragmentation.

3) The emulsion-based fortified microcapsules are transferred to a continuous water phase via a process of dialysis or centrifugation for solvent exchange.

Fig. 2 Schematic illustration of the synthetic route of colloidosomes. (Wei M, et al. 2023)

Our Colloidosomes Technology

Ensuring the stability of colloidosomes is critical for their successful utilization. Here are some of our techniques for preparing stable colloidosomes:

• Pickering Emulsions.
• Layer-by-Layer Assembly.
• Chemical Cross-Linking.
• Temperature-Responsive Polymers.
• Hydrogel Encapsulation.
• Electrostatic Interactions.
• Microfluidic Techniques.
• Template-Assisted Methods.
• Surface Modification.
• Composite Colloidosomes.

Contact us today to discuss your colloidosome development needs and embark on an exciting journey of innovation.