Coated Microneedle Development Services

Protheragen-ING specializes in the development and manufacturing of coated microneedle technology to provide innovative solutions for drug delivery systems. By coating the surface of microneedles with different drugs or carriers, we are able to further enhance their drug delivery capabilities and biocompatibility, providing patients with more convenient and effective treatments. Whether you need to customize an existing coating method or develop a new coating, our team of skilled professionals is ready to assist you.

The Concept of Coated Microneedless

Coated microneedles are an emerging multifunctional delivery system that can be used to deliver a wide range of materials, including small molecules, proteins, DNA, viruses, and even particles.

Coated microneedles contain sharp, solid microneedle structures coated with a solid membrane containing an active compound and a water-soluble inactive excipient. When a drug-coated microneedle is inserted into the skin, the coating encounters interstitial fluid present in the tissue, contact with which helps to dissolve the water-soluble excipients in the coating, which in turn triggers the separation of the coating from the microneedle surface. Coated microneedles can be used to deliver their coating payload not only to the skin but also to other tissues.

Fig. 1 The process by which a coated microneedle delivers its payload into the skin is schematically. (Ingrole RSJ, et al. 2019)

Our Coating Approach

In our coated microneedle development services, we utilize advanced coating technology to ensure that the drug is uniformly distributed on the microneedle surface and provides optimal drug release properties. Our team of experts will develop the optimal coating solution according to the client's requirements and drug properties to ensure the stability and activity of the drug during delivery.

Coating Methods That Selectively Coat the Microneedle Shafts without Contaminating the Base Substrate of the Microneedle Array

• Dip Coating (Masked dip coating, Thin-film dip coating, Factors affecting dip coating).
• Inkjet Printing.

Coating Methods Shown to Coat Both the Microneedle Shafts and the Microneedle Array Base Substrate

• Immersion Coating.
• Drop Coating.
• Spray Coating.
• Layer-by-Layer Coating.

Our Services

We offer a comprehensive range of coated microneedle development services to meet the unique needs of our clients. Our team of experts works closely with you to understand your specific requirements and provide customized solutions. Our services include:

• Formulation development - We work with you to develop drug formulations suitable for microneedle coating, ensuring compatibility and stability throughout the delivery process.
• Coated microneedle design and manufacturing - Based on customer requirements, we can design and manufacture microneedles with specific geometries and sizes to meet different drug delivery needs.
• Coating material selection - We assist in the selection of the most suitable coating material based on the characteristics of the drug compound and the desired release profile.
• Coating optimization and process development - Our team of experts will perform coating process optimization and development to ensure uniform drug distribution and stability on the microneedle surface.
• Drug delivery performance evaluation - We will conduct a comprehensive evaluation of the drug delivery performance of the coated microneedles, including drug release rate, transdermal absorption performance, and drug stability.
• Drug compatibility and safety assessment - We will evaluate the compatibility between the coated microneedles and the drug to ensure drug safety and efficacy.

Benefits of Our Microneedle Coatings

We develop and manufacture microneedle coatings that offer several benefits, including:

• Improved drug delivery efficiency: By precisely controlling the coating process and drug distribution, we can improve the efficiency of drug delivery and achieve higher drug concentrations in the target tissue or blood circulation.
• Enhanced drug absorption: The design and coating method of microneedles can improve the transdermal absorption of drugs and increase the bioavailability of drugs.
• Improve drug stability: Through coating technology, we can protect the drug from external environmental influences and increase the stability and shelf life of the drug.
• Provide personalized treatment: According to the customer's needs and drug characteristics, we can customize a specific coating scheme to achieve personalized drug delivery to meet the needs of different patients.

If you are interested in our services or have any questions, please feel free to contact our team. We look forward to working with you to promote the innovation and application of coated microneedle technology.