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Cat Number: API25122467

Clobetasol propionate

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APIs
CAS Number
25122-46-7
Description
Clobetasol Propionate is an anti-inflammatory, antipruritic and vasoconstrictive agent.
MolecularWeight
466.98
MolecularFormula
C25H32ClFO5
Appearance
Crystalline powder
Solubility
Soluble in water
Storage
Store at 4℃
MeltingPoint
195℃
BoilingPoint
~569.0℃ at 760 mmHg
Density
~1.3 g/cm3
RefractiveIndex
1.56
OpticalActivity
α20D +101±2, c = 1 in dioxane
IC50
GR: IC50 = 1.46 nM (human); Glucocorticoid receptor: IC50 = 3.17 nM (rat); Progesterone receptor: IC50 = 12 nM (bovine); Androgen Receptor: IC50 = 3.78 µM (rat); Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells: EC5050 = 25 µM
pKValue
pKa: 12.88
FlashPoint
297.9±30.1 ℃
VapourPressure
0.0±3.5 mmHg at 25℃
PreparationUse
topical corticosteroid For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
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