Cat Number: API298464

Carbamazepine

APIs
CAS Number
298-46-4
Description
Carbamazepine is a sodium channel protein inhibitor.
MolecularWeight
236.27
MolecularFormula
C15H12N2O
Appearance
Crystalline
Solubility
Soluble in ethanol (25 mM), acetone, propylene glycol, chloroform (1:10), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (29 mg/ml), DMSO (100 mM), methanol, DMF, and ethylene glycol monoethyl ether. Slightly soluble in glacial acetic acid.Insoluble in water.
Storage
Store at 4℃
MeltingPoint
191-192℃ (lit.)
BoilingPoint
~411.0℃ at 760 mmHg
Density
~1.3 g/cm3
RefractiveIndex
1.67
IC50
Sodium channel protein type VIII alpha subunit: IC50 = 30 µM (rat); Sodium channel protein type IX alpha subunit: IC50 = 22 µM (human); Sodium channel protein type VI alpha subunit: IC50 = 30 µM (rat); Sodium channel protein type V alpha subunit: IC50 = 30 µM (rat)
pKValue
pKa: 13.94
PreparationUse
Anticonvulsant
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