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Cat Number: API633658

Berberine HCl

CAS Number

633-65-8

Description

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis.

MolecularWeight

371.81

MolecularFormula

C20H17NO4•HCl

SMILEs

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

Appearance

Granular

Solubility

Soluble in water

Storage

Store at -20℃

MeltingPoint

193-196℃ (dec.)

IC50

AChE: IC50 = 40 nM (human); Plasmodium falciparum D6: IC50 = 0.14 ug.mL-1; Plasmodium falciparum W2: IC50 = 0.15 ug.mL-1; Plasmodium falciparum K1: IC50 = 0.36 ug.mL-1; SrtA: IC50 = 8.7 ug.mL-1 (Staphylococcus aureus subsp. aureus N315)

PreparationUse

Antimicrobial, antiarrhythmic, hypolipidemic, hypoglycemic, anti-inflammatory, antitumor, sedative hypnosis and other pharmacological effects.

Standard

CP2005, CP2015, JP17

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION