Cat Number: API104314

Benzonatate

APIs
CAS Number
104-31-4
Description
Benzonatate is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite.
MolecularWeight
603.742
MolecularFormula
C30H53NO11
SMILEs
CCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC
Solubility
Soluble in water (0.005 mg/ml at 20℃), ethanol, methanol, toluene, and chloroform.
Storage
Store at 2-8℃
Density
1.096 g/cm3
RefractiveIndex
1.495
pKValue
pKa: 3.03, pKb: 2.2
FlashPoint
346.3ºC
VapourPressure
9.98E-17mmHg at 25℃
PreparationUse
a reversible voltage-gated sodium channel blocker, used as antitussive agents for the treatment of coughs.
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