Cat Number: API4474913

Angiotensin

Inquiry

CAS Number

4474-91-3

Description

Angiotensin II, Human is a peptide involved in the regulation of blood pressure

MolecularWeight

1046.18

MolecularFormula

C50H71N13O12

SMILEs

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N

Sequence

Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser- Gly-Thr-Pro-NH2

Solubility

Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).

Density

1.43 g/cm³

RefractiveIndex

1.66

IC50

Type-1B angiotensin II receptor: IC50 = 0.4 nM (rat); Type-1A angiotensin II receptor: IC50 = 0.4 nM (rat); AT-1: IC50 = 1.5 nM (rat); Angiotensin II receptor: IC50 = 4 nM (human)

PreparationUse

is a peptide hormone of the RAAS system used to raise blood pressure in septic or other forms of shock.

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