Cat Number: API5508587

Andrographolide

CAS Number

5508-58-7

Description

Andrographolide is a bicyclic diterpenoid lactone displaying antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties. This chemical is an irreversible antagonist of NF-κB and prevents in vitro T cell activation. Andrographolide displays no effect on IκBa degradation but downregulates iNOS and Mac-1 expressions and ROS production. It has been shown to prevent endotoxin shock in mouse models and is reported to activate PI 3K/Akt pathways. Andrographolide is also an inhibitor of ERK.

MolecularWeight

350.449

MolecularFormula

C20H30O5

SMILEs

C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\\[C@@H](COC3=O)O)(C)CO)O

Appearance

Powder

Solubility

Soluble in acetone, methanol, chloroform, ether, water (Partly miscible), and DMSO.

Storage

Store at 4℃