Cat Number: API5508587

Andrographolide

APIs
CAS Number
5508-58-7
Description
Andrographolide is a bicyclic diterpenoid lactone displaying antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties. This chemical is an irreversible antagonist of NF-κB and prevents in vitro T cell activation. Andrographolide displays no effect on IκBa degradation but downregulates iNOS and Mac-1 expressions and ROS production. It has been shown to prevent endotoxin shock in mouse models and is reported to activate PI 3K/Akt pathways. Andrographolide is also an inhibitor of ERK.
MolecularWeight
350.449
MolecularFormula
C20H30O5
SMILEs
C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\\[C@@H](COC3=O)O)(C)CO)O
Appearance
Powder
Solubility
Soluble in acetone, methanol, chloroform, ether, water (Partly miscible), and DMSO.
Storage
Store at 4℃
MeltingPoint
229-232ºC
BoilingPoint
557.3±50.0 ℃ at 760 mmHg
Density
1.2±0.1 g/cm3
RefractiveIndex
1.568
OpticalActivity
α20D -126, c = 1.5 in acetic acid
IC50
NF-κB and AP-1 activation: IC50 = ≤ 15 µM (T cell)
pKValue
pKa: 12.32
FlashPoint
195.5±23.6 ℃
VapourPressure
0.0±3.4 mmHg at 25℃
PreparationUse
anti-inflammatory, anti-bacterial
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