Cat Number: API5508587

Andrographolide

CAS Number

5508-58-7

Description

Andrographolide is a bicyclic diterpenoid lactone displaying antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties. This chemical is an irreversible antagonist of NF-κB and prevents in vitro T cell activation. Andrographolide displays no effect on IκBa degradation but downregulates iNOS and Mac-1 expressions and ROS production. It has been shown to prevent endotoxin shock in mouse models and is reported to activate PI 3K/Akt pathways. Andrographolide is also an inhibitor of ERK.

MolecularWeight

350.449

MolecularFormula

C20H30O5

SMILEs

C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\\[C@@H](COC3=O)O)(C)CO)O

Appearance

Powder

Solubility

Soluble in acetone, methanol, chloroform, ether, water (Partly miscible), and DMSO.

Storage

Store at 4℃

MeltingPoint

229-232ºC

BoilingPoint

557.3±50.0 ℃ at 760 mmHg

Density

1.2±0.1 g/cm³

RefractiveIndex

1.568

OpticalActivity

α20D -126, c = 1.5 in acetic acid

IC50

NF-κB and AP-1 activation: IC50 = ≤ 15 µM (T cell)

pKValue

pKa: 12.32

FlashPoint

195.5±23.6 ℃

VapourPressure

0.0±3.4 mmHg at 25℃

PreparationUse

anti-inflammatory, anti-bacterial

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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