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Cat Number: API111470996

Amlodipine Besylate

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CAS Number

111470-99-6

Description

Amlodipine besylate is a calcium channel protein inhibitor.

Molecular Weight

567.05

Molecular Formula

C20H25ClN2O5•C6H6O3S

Solubility

Soluble in DMSO (≥20 mg/mL), water (10 mM), chloroform, ethanol (≥14 mg/mL), and methanol.

Storage

Store at 4℃

SMILES

CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

Appearance

Crystalline powder

pKa

8.6

Boiling Point

527.2℃ at 760 mmHg

Density, g/cm3

1.227

IC50

Ca2+-induced contractions : IC50 = 1.9 nM (depolarized rat aorta); proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells: IC50 = 25 µM; bTREK-1: IC50 = 0.43 µM; 35 mM KCl-induced contractions of pig coronary artery rings: IC50 = 22 nM; 35 mM KCl-induced contractions of human coronary artery rings: IC50 = 21 nM

Melting Point

195-204℃

Flash Point

272.6ºC

Vapour Pressure

3.34E-11mmHg at 25℃

Standard

CP/EP/JP
Facility GMP

Preparation Use

A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive

Qualification

CDE