Cat Number: INT3680691

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

CAS Number

3680-69-1

Synonyms

4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE;4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;6-CHLORO-7-DEAZAPURINE;6-CHLORO-7-DEAZAPURINE 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 6-CHLORO-7-DEAZAPURIN;4-Chloro-1H-pyrrolo[2,3-d]pyrimidine4-Chloropyrrolo[2,3-d]pyrimidine;6-Chloro-7-deazapurin;4-CHLORO-4H-PYRROLO[2,3-D]PYRIMIDINE

Description

4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response.

Molecular Weight

153.57

Molecular Formula

C6H4ClN3

InChI

BPTCCCTWWAUJRK-UHFFFAOYSA-N

InChIKey

BPTCCCTWWAUJRK-UHFFFAOYSA-N

SMILES

C1=NC(Cl)=C2C=CNC2=N1

Appearance

Crystalline Powder

Color

White to tan

Storage

Keep in dark place,Inert atmosphere, 2-8 ℃

pKa

11.42±0.20(Predicted)

Boiling Point

289.2±50.0 ℃(Predicted)

Density, g/cm3

1.61±0.1(Predicted)

Melting Point

188-194 ℃

Vapour Pressure

0Pa at 25℃

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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