Cat Number: INT3680691

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

APIs
CAS Number
3680-69-1
Synonyms
4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE;4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;6-CHLORO-7-DEAZAPURINE;6-CHLORO-7-DEAZAPURINE 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 6-CHLORO-7-DEAZAPURIN;4-Chloro-1H-pyrrolo[2,3-d]pyrimidine4-Chloropyrrolo[2,3-d]pyrimidine;6-Chloro-7-deazapurin;4-CHLORO-4H-PYRROLO[2,3-D]PYRIMIDINE
Description
4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response.
Molecular Weight
153.57
Molecular Formula
C6H4ClN3
InChI
BPTCCCTWWAUJRK-UHFFFAOYSA-N
InChIKey
BPTCCCTWWAUJRK-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=C2C=CNC2=N1
Appearance
Crystalline Powder
Color
White to tan
Storage
Keep in dark place,Inert atmosphere, 2-8 ℃
pKa
11.42±0.20(Predicted)
Boiling Point
289.2±50.0 ℃(Predicted)
Density, g/cm3
1.61±0.1(Predicted)
Melting Point
188-194 ℃
Vapour Pressure
0Pa at 25℃
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