Cat Number: PIPE-0648

3,4`,5-Trimethoxy-trans-stilbene

CAS Number

22255-22-7

Synonyms

trans-Trimethoxyresveratrol (E)-1,3-Dimethoxy-5-(4-methoxystyryl)benzene (E)-3,5,4'-Trimethoxystilbene

Description

3,4',5-Trimethoxystilbene is isolated from the herbs of Virola cuspidata. 3,4',5-Trimethoxystilbene exerts antiallergic and anti-mitotic properties. It shows antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. 3,4',5-Trimethoxystilbene is a potent small molecule inducer of autophagy in human umbilical vascular endothelial cells (HUVECs) in the presence of serum. It has anti-inflammatory activity, the ability of it to induce HO-1 expression may provide one of possible mechanisms of its anti-inflammatory action. 3,4',5-Trimethoxystilbene shows potent antitumor and anti-HCV activities without exhibiting cytotoxicity to human hepatocytes in vitro or in mice livers. It acts as an inhibitor of tubulin polymerization.

Molecular Weight

270.32

Molecular Formula

C17H18O3

EINECS

694-659-7

SMILES

COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC

Appearance

Powder

Storage

Room temperature