Cat Number: INT151266238

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS Number

151266-23-8

Synonyms

3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE;4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;4-Amino-3-iodopyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;7-Iodo-7-deaza-8-aza-adenine

Description

3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Molecular Weight

261.02

Molecular Formula

C5H4IN5

InChI

HQAIUXZORKJOJY-UHFFFAOYSA-N

InChIKey

HQAIUXZORKJOJY-UHFFFAOYSA-N

SMILES

C1=NC(N)=C2C(I)=NNC2=N1

Appearance

powder to Crystal