Cat Number: API68962

17α-Hydroxyprogesterone

APIs
CAS Number
68-96-2
Description
17a-Hydroxyprogesterone is an antiestrogen compound.
MolecularWeight
330.461
MolecularFormula
C21H30O3
SMILEs
CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
Appearance
Crystalline
Solubility
Soluble in water (partly), chloroform, methanol, and Dichloromethane.
Storage
Store at -20℃
MeltingPoint
276℃
BoilingPoint
482.9±45.0 ℃ at 760 mmHg
Density
1.2±0.1 g/cm3
RefractiveIndex
1.56
OpticalActivity
α20D +92.1, c = 1.0 in chloroform; α20D +90±5, c = 1 in chloroform
IC50
Progesterone receptor: IC50 = 12 nM (bovine); GR: IC50 = 51 nM (human); Androgen Receptor: IC50 = 739 nM (rat); ERK 1: IC50 = 3.16 µM (human); Plasmodium falciparum W2: IC50 = 3.16 µM
pKValue
pKa: 13.03
FlashPoint
260.0±25.2 ℃
VapourPressure
0.0±2.8 mmHg at 25℃
PreparationUse
a metabolite of Progesterone, used prophylactically for the 12th to 37th week of pregnancy, particularly in women who are in the high-risk category for premature delivery-anticoagulant
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