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Cat Number: PIPE-0601

10-Hydroxycamptothecin

Inquiry

CAS Number

19685-09-7

Synonyms

(S)-10-Hydroxycamptothecin
Hydroxycamptothecin
10-hydroxycamptothecine

Description

10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin is also an impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer.

Molecular Weight

364.4

Molecular Formula

C20H16N2O5

EINECS

805-668-4

SMILES

CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O

Appearance

Light Yellow to Yellow Solid

Storage

Room temperature