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Cat Number: PIPE-0601

10-Hydroxycamptothecin

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APIs
CAS Number
19685-09-7
Synonyms
(S)-10-Hydroxycamptothecin
Hydroxycamptothecin
10-hydroxycamptothecine
Description
10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin is also an impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer.
Molecular Weight
364.4
Molecular Formula
C20H16N2O5
EINECS
805-668-4
SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
Appearance
Light Yellow to Yellow Solid
Storage
Room temperature
Purity
HPLC≥98%
Boiling Point
820.7±65.0℃ at 760 mmHg
Density, g/cm3
1.60±0.1
Melting Point
268-270℃
Expiration Time
2years
Applications
anti-cancer
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