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Cat Number: API1077287

α-Lipoic Acid

CAS Number

1077-28-7

Description

α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation.

MolecularWeight

206.326

MolecularFormula

C8H14O2S2

SMILEs

C1CSSC1CCCCC(=O)O

Solubility

Soluble in water (1 g/l at 20℃), ethanol (50 mg/ml), ethanol:PBS (pH 7.2) (1:8), DMSO, DMF, 10% sodium hydroxide solution, and methanol.

Storage

Store at 4℃

MeltingPoint

60-62ºC

BoilingPoint

173.0±19.3 ℃

Density

1.22 g/cm³

RefractiveIndex

1.562

OpticalActivity

α20D 0±1.0, c = 1 in toluene

IC50

SUMO-activating enzyme: IC50 = 620 nM (human); Eukaryotic translation initiation factor 4E: IC50 = 16.56 µM (mouse); Bifunctional protein glmU: IC50 = 3.91 µM (Mycobacterium tuberculosis)

pKValue

pKa: 4.75

FlashPoint

173.0±19.3 ℃

VapourPressure

0.0±1.7 mmHg at 25℃

PreparationUse

a lipophilic endogenous disulfide that can be reduced to the dithiol dihydrolipoic acid, protects against free-radical-mediated injury both in vivo and in vitro

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Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

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