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Cat Number: API1077287

α-Lipoic Acid

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APIs
CAS Number
1077-28-7
Description
α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation.
MolecularWeight
206.326
MolecularFormula
C8H14O2S2
SMILEs
C1CSSC1CCCCC(=O)O
Solubility
Soluble in water (1 g/l at 20℃), ethanol (50 mg/ml), ethanol:PBS (pH 7.2) (1:8), DMSO, DMF, 10% sodium hydroxide solution, and methanol.
Storage
Store at 4℃
MeltingPoint
60-62ºC
BoilingPoint
173.0±19.3 ℃
Density
1.22 g/cm3
RefractiveIndex
1.562
OpticalActivity
α20D 0±1.0, c = 1 in toluene
IC50
SUMO-activating enzyme: IC50 = 620 nM (human); Eukaryotic translation initiation factor 4E: IC50 = 16.56 µM (mouse); Bifunctional protein glmU: IC50 = 3.91 µM (Mycobacterium tuberculosis)
pKValue
pKa: 4.75
FlashPoint
173.0±19.3 ℃
VapourPressure
0.0±1.7 mmHg at 25℃
PreparationUse
a lipophilic endogenous disulfide that can be reduced to the dithiol dihydrolipoic acid, protects against free-radical-mediated injury both in vivo and in vitro
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